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Sports Med. 2003;33(10):771-81.

Elucidating the unexplained underperformance syndrome in endurance athletes : the interleukin-6 hypothesis.

Author information

1
UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Sports Science Institute of South Africa, University of Cape Town, Newlands, South Africa. paularobson@emailacc.com

Abstract

The unexplained underperformance syndrome (UPS), previously known as the overtraining syndrome (OTS), has been defined as a persistent decrement in athletic performance capacity despite 2 weeks of relative rest. It has been proposed that UPS may be caused by excessive cytokine release during and following exercise causing a chronic inflammatory state and 'cytokine sickness'. This article extends that hypothesis by proposing that time-dependent sensitisation could provide a model through which the aetiology of UPS may be explained. In this model, the principal abnormal factors in UPS are an increased production of and/or intolerance to interleukin (IL)-6 during exercise. Strategies to attenuate the IL-6 response to exercise that may also reduce an athlete's susceptibility to UPS are proposed.

[Indexed for MEDLINE]

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