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Nat Rev Cancer. 2003 Aug;3(8):601-14.

Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms.

Author information

1
Strang Cancer Prevention Center and Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA. lampres@mail.rockefeller.edu

Abstract

Recent findings have indicated that dietary calcium, vitamin D and folate can modulate and inhibit colon carcinogenesis. Supporting evidence has been obtained from a wide variety of preclinical experimental studies, epidemiological findings and a few human clinical trials. Important molecular events and cellular actions of these micronutrients that contribute to their tumour-modulating effects are discussed. They include a complex series of signalling events that affect the structural and functional organization of colon cells.

PMID:
12894248
DOI:
10.1038/nrc1144
[Indexed for MEDLINE]

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