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Nat Rev Cancer. 2003 Aug;3(8):582-91.

The emerging role of lysophosphatidic acid in cancer.

Author information

1
MD Anderson Cancer Center, Houston, Texas 77030, USA. gmills@mdanderson.org

Abstract

The bioactive phospholipid lysophosphatidic acid (LPA) stimulates cell proliferation, migration and survival by acting on its cognate G-protein-coupled receptors. Aberrant LPA production, receptor expression and signalling probably contribute to cancer initiation, progression and metastasis. The recent identification of ecto-enzymes that mediate the production and degradation of LPA, as well as the development of receptor-selective analogues, indicate mechanisms by which LPA production or action could be modulated for cancer therapy.

PMID:
12894246
DOI:
10.1038/nrc1143
[Indexed for MEDLINE]

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