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Ann Neurol. 2003 Aug;54(2):235-8.

Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs.

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1
MRC Building, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom. e.k.perry@ncl.ac.uk

Abstract

The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.

PMID:
12891676
DOI:
10.1002/ana.10639
[Indexed for MEDLINE]
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