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Org Lett. 2003 Aug 7;5(16):2955-7.

Regioselective formation, using orthogonal cysteine protection, of an alpha-conotoxin dimer peptide containing four disulfide bonds.

Author information

1
Amersham Health AS, Department of Medicinal Chemistry, Oslo, Norway. alan.cuthbertson@amersham.com

Abstract

[structure: see text] The combination of the cysteine thiol protecting groups Trt, Acm, tBu, and MeBzl were used for the regioselective formation of an alpha-conotoxin dimer peptide containing four disulfide bridges. Additionally, a protocol is described whereby two one-pot oxidations were employed in order to improve the efficiency of the folding process. The target compound was produced in good yield.

PMID:
12889917
DOI:
10.1021/ol035105w
[Indexed for MEDLINE]

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