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Trends Cell Biol. 2003 Aug;13(8):393-6.

An uncertainty principle in chromosome positioning.

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1
National Cancer Institute, Bethesda, MD 20892, USA.

Abstract

Chromosomes are non-randomly positioned in the mammalian interphase nucleus. It is not known how patterns of chromosome positions are established or to what degree spatial arrangements of chromosomes change during the cell cycle, especially during mitosis. Two reports have applied in vivo microscopy to track chromosomes in space and time. The results highlight the inherently imperfect and probabilistic nature of chromosome positioning in the cell nucleus.

PMID:
12888289
[Indexed for MEDLINE]
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