Format

Send to

Choose Destination
Curr Opin Genet Dev. 2003 Aug;13(4):341-50.

Cell polarity: the ups and downs of the Par6/aPKC complex.

Author information

1
Instituto Medicina Molecular, Faculdade de Medicina de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Portugal. henrique@fm.ul.pt

Abstract

A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.

PMID:
12888006
DOI:
10.1016/s0959-437x(03)00077-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center