Format

Send to

Choose Destination
Cell. 2003 Jul 25;114(2):157-9.

Loading Rho to terminate transcription.

Author information

1
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405, USA. richardj@indiana.edu

Abstract

In bacteria, one of the major transcriptional termination mechanisms requires a hexameric RNA/DNA helicase known as Rho. One question that has remained unanswered is how the helicase loads onto a nascent transcript so that it can initiate actions on the transcript to cause termination. Recent structures of Rho bound to nucleic acid by show how the individual RNA-binding domains of the 6 subunits are organized and that the ring is split open. The opening is wide enough to accommodate single-stranded RNA and suggests that this conformation is poised to load onto mRNA.

PMID:
12887917
DOI:
10.1016/s0092-8674(03)00554-3
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center