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Biochem J. 2003 Sep 15;374(Pt 3):607-11.

Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.

Author information

1
Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK.

Abstract

Mitochondrial pyruvate transport is fundamental for metabolism and mediated by a specific inhibitable carrier. We have identified the yeast mitochondrial pyruvate carrier by measuring inhibitor-sensitive pyruvate uptake into mitochondria from 18 different Saccharomyces cerevisiae mutants, each lacking an unattributed member of the mitochondrial carrier family (MCF). Only mitochondria from the YIL006w deletion mutant exhibited no inhibitor-sensitive pyruvate transport, but otherwise behaved normally. YIL006w encodes a 41.9 kDa MCF member with homologous proteins present in both the human and mouse genomes.

PMID:
12887330
PMCID:
PMC1223651
DOI:
10.1042/BJ20030995
[Indexed for MEDLINE]
Free PMC Article

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