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Biochem Soc Trans. 2003 Aug;31(Pt 4):785-90.

Bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP): structure, function and regulation in host defence against Gram-negative bacteria.

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Departments of Internal Medicine and Microbiology, Division of Infectious Diseases and The Inflammation Program, Roy J. and Lucille A. Carver, College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.


Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are closely related endotoxin-binding proteins that function in a co-ordinated manner to facilitate an integrated host response to invading Gram-negative bacteria. Differences in the structure and function of BPI and LBP, as well as differences in their mobilization, permit highly sensitive pro-inflammatory responses to small numbers of bacteria at the onset of bacterial invasion and, later, efficient elimination of viable bacteria and their remnants and of endotoxin-driven inflammation.

[Indexed for MEDLINE]

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