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Neuropsychol Rev. 2003 Jun;13(2):79-92.

Alzheimer's disease as a disconnection syndrome?

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Cognitive Psychopathology Unit, University of Geneva, Geneva, Switzerland.


This paper reviews the growing amount of evidence supporting the hypothesis that Alzheimer's disease includes a disconnection syndrome. This evidence came mainly from neuropathological, electrophysiological, and neuroimaging studies. Moreover, a few recent neuropsychological studies have also explored the effects of a disconnection between cerebral areas on cognitive functioning. Finally, and more generally, the contribution of this interpretation to the understanding of Alzheimer's disease cognitive deficits is considered.

[Indexed for MEDLINE]

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