Format

Send to

Choose Destination
Expert Opin Ther Targets. 2003 Aug;7(4):559-73.

Cellular FLICE-inhibitory protein: an attractive therapeutic target?

Author information

1
INSERM 517, IFR100, Faculty of Medicine, 7 Boulevard Jeanne d'Arc, 21079 Dijon cedex, France. omicheau@u-bourgogne.fr

Abstract

Cellular FLIP (c-FLIP), also known as FLICE-inhibitory protein, has been identified as an inhibitor of apoptosis triggered by engagement of death receptors (DRs) such as Fas or TRAIL (TNF-related apoptosis-inducing ligand). cFLIP is recruited to DR signalling complexes, where it prevents caspase activation. Animal models have indicated that c-FLIP plays an important role in T cell proliferation and heart development. Abnormal c-FLIP expression has been identified in various diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), diabetes mellitus, rheumatoid arthritis (RA) and various cancers. This review focuses on recent insights into c-FLIP dysregulation associated with human diseases and addresses the possibilities of using c-FLIP as a therapeutic target.

PMID:
12885274
PMCID:
PMC2984612
DOI:
10.1517/14728222.7.4.559
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center