Send to

Choose Destination
Cancer Metastasis Rev. 2003 Dec;22(4):405-22.

Deregulation of NF-kappaB and its upstream kinases in cancer.

Author information

Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA.


The transcription factor NF-kappaB is known for its function in regulating immune and inflammatory responses. However, recent evidence suggests that NF-kappaB also plays a pivotal role in controlling cell proliferation, apoptosis, and cell migration. Deregulated activation of NF-kappaB has been observed in various cancers. Over the past few years. significant progress has been made to elucidate the mechanisms of NF-kappaB activation in both normal and cancer cells. Notably, a large number of protein kinases have been shown to stimulate NF-kappaB activity under different conditions, and some of these kinases are aberrantly activated in cancer cells. In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center