Format

Send to

Choose Destination
Cancer Metastasis Rev. 2003 Dec;22(4):405-22.

Deregulation of NF-kappaB and its upstream kinases in cancer.

Author information

1
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA. sxs70@psu.edu

Abstract

The transcription factor NF-kappaB is known for its function in regulating immune and inflammatory responses. However, recent evidence suggests that NF-kappaB also plays a pivotal role in controlling cell proliferation, apoptosis, and cell migration. Deregulated activation of NF-kappaB has been observed in various cancers. Over the past few years. significant progress has been made to elucidate the mechanisms of NF-kappaB activation in both normal and cancer cells. Notably, a large number of protein kinases have been shown to stimulate NF-kappaB activity under different conditions, and some of these kinases are aberrantly activated in cancer cells. In this review, we discuss our current knowledge of NF-kappaB activation, with a focus on the NF-kappaB-activating kinases and their roles in cancer formation.

PMID:
12884915
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center