Format

Send to

Choose Destination
Nat Neurosci. 2003 Sep;6(9):911-2.

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.

Author information

1
Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental Medicine, D-37075 Goettingen, Germany.

Abstract

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.

PMID:
12883553
DOI:
10.1038/nn1101
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center