Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Crit Care. 2003 Aug;9(4):266-70.

Antioxidant therapy in intensive care.

Author information

1
Department of Intensive Care Centre hospitalo-Universitaire du Sart-Tilman, LiƩge, Belgium.

Abstract

PURPOSE OF REVIEW:

This review intends to summarize the recent findings regarding the presence of increased oxidative stress in critically ill patients and its potential pathophysiologic role, as well as the results of recent clinical trials of antioxidant therapies.

RECENT FINDINGS:

Several lines of evidence confirm the increase in oxidative stress during critical illness. The oxidative damage to cells and tissues eventually contributes to organ failure. Prophylactic administration of antioxidant vitamins or glutamine, incorporated in the nutritional support or given as separate medications, efficiently attenuates the oxidative stress and in some studies improves the outcome of critically ill patients. Few data on the effects of N-acetylcysteine or trace elements have been published during the last two years.

SUMMARY:

Patients at risk of organ failure could benefit from the early adjunction of antioxidant treatment, including vitamins and glutamine.

PMID:
12883280
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center