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Cerebellum. 2002 Apr;1(2):111-8.

Genetic targeting of cerebellar Purkinje cells: history, current status and novel strategies.

Author information

1
Max-Planck-Institute of Neurobiology, Department of Neurobiochemistry, Martinsried, Germany. barski@neuro.mpg.de

Abstract

This review is an account of developments in the field of transgenic and gene targeting approaches with special emphasis on the cerebellar Purkinje cell. A critical discussion of the available genetic tools is provided. As genetic engineering of the mouse is still a rapidly moving field, we felt it appropriate to include some ideas on novel strategies for refined genetic manipulations.

PMID:
12882360
DOI:
10.1080/147342202753671240
[Indexed for MEDLINE]

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