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Biotechnol Lett. 2003 Mar;25(6):461-4.

Improving lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester in organic solvent by in situ racemization.

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1
Department of Chemical Engineering, Tsinghua University, 100084 Beijing, PR China. duwei@mail.tsinghua.edu.cn

Abstract

Lipase-catalyzed enantioselective ammonolysis of phenylglycine methyl ester was processed by in situ racemization with ammonium carbamate as the acyl acceptor. Using 1 mM benzaldehyde or 0.6 mM chloropyridoxal as the racemizing catalyst, 80% substrate conversion with an enantiomeric excess of the product of 95% were achieved at 20 degrees C after 7 h reaction.

PMID:
12882271
[Indexed for MEDLINE]
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