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Clin Nutr. 2003 Aug;22(4):379-84.

Virgin olive and fish oils enhance the hepatic antioxidant defence system in atherosclerotic rabbits.

Author information

1
Department of Biochemistry and Molecular Biology University of Granada, C/Ramón y Cajal 4 18071-Granada, Spain.

Abstract

BACKGROUND & AIMS:

In this study we report the effects of sunflower, virgin olive and fish oils on the lipid profile and antioxidant defence system in liver mitochondria from rabbits with experimental atherosclerosis.

METHOD:

An atherogenic control group were fed for 50 days on a diet containing 3% lard and 1.3% cholesterol. Four groups were fed for an additional period of 30 days with a diet enriched in different oils: sunflower oil, virgin olive oil, refined olive oil and fish oil. A control group was fed with a standard chow.

RESULTS:

The atherogenic diet caused important changes in the hepatic mitochondria lipid profile and in the enzymatic and non-enzymatic antioxidant defence system accompanied with an increase in the content of hydroperoxides in liver mitochondria. The administration of virgin olive and fish oils showed a better profile in the antioxidant system as well as decrease in the content of hydroperoxides.

CONCLUSIONS:

The intake of cholesterol- and lard-enriched diet leads to a high impairment in the hepatic antioxidant defence system. However, the replacement of that diet by other unsaturated fat-enriched diets using virgin olive, sunflower and fish oil enhances hepatic antioxidant defence system, virgin olive and fish oil diet provide the best results.

PMID:
12880605
[Indexed for MEDLINE]

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