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Expert Rev Mol Diagn. 2003 Jul;3(4):443-58.

Methylated DNA as a possible screening marker for neoplastic disease in several body fluids.

Author information

1
Department of Obstetrics and Gynecology, Innsbruck University Hospital, Austria. Hannes.Mueller@uibk.ac.at

Abstract

Early detection appears to be one of the most important approaches to reducing mortality caused by neoplasia. Changes in DNA methylation have been recognized as one of the most common molecular alterations in human tumors. Due to the ubiquity of DNA methylation changes and the possibility to detect methylated DNA in several body fluids, this specifically altered DNA may serve as a potential new screening marker for neoplastic disease.

PMID:
12877384
DOI:
10.1586/14737159.3.4.443
[Indexed for MEDLINE]

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