Olfactory dysfunction in hereditary ataxia and basal ganglia disorders

Neuroreport. 2003 Jul 18;14(10):1339-41. doi: 10.1097/01.wnr.0000077551.91466.d3.

Abstract

In the present study the olfactory system of hereditary ataxia patients was tested using the smell identification test. Two previous findings suggested a possible olfactory impairment in these patients. First, an olfactory dysfunction has been found in different neurodegenerative diseases, and second, human functional imaging has shown cerebellar activation during olfaction. As an initial approach to determine if cerebellar ataxia impairs the olfactory process, cerebellar ataxia patients, along with basal ganglia patients, were tested. The results show an olfactory deficit in both basal ganglia and hereditary ataxia patients. Further exploration of the olfactory capacities in hereditary ataxia is necessary to elucidate the specific nature of the deficits.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Basal Ganglia Diseases / complications*
  • Basal Ganglia Diseases / physiopathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Olfaction Disorders / etiology*
  • Psychiatric Status Rating Scales
  • Smell / physiology
  • Spinocerebellar Degenerations / complications*
  • Spinocerebellar Degenerations / physiopathology*