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Hum Pathol. 2003 Jul;34(7):717-9.

Invasive thymoma with paraneoplastic retinopathy.

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1
Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.

Abstract

A 60-year-old man was admitted for progressive visual loss in both eyes. He was diagnosed with retinopathy and chest computed tomography revealed an invasive thymoma. In western blot analysis, serum autoantibodies against recoverin, photoreceptor-specific calcium-binding protein, and heat shock cognate protein 70 which were identified as the cause of cancer-associated retinopathy (CAR). Immunofluorescence staining showed that thymoma cells also expressed recoverin. These observations strongly suggested that similar pathogenesis of CAR was involved in the presented case.

PMID:
12874770
[Indexed for MEDLINE]
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