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J Exp Med. 2003 Jul 21;198(2):249-58.

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.

Author information

  • 1MRC Centre for Immune Regulation, University of Birmingham Medical School, Vincent Drive, Birmingham B15 2TT, United Kingdom. L.S.Walker@bham.ac.uk

Abstract

The failure of CD25+ regulatory T cells (Tregs) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use Tregs expressing a transgenic TCR to show that despite anergy in vitro, Tregs proliferate in response to immunization in vivo. Tregs also proliferate and accumulate locally in response to transgenically expressed tissue antigen whereas their CD25- counterparts are depleted at such sites. Collectively, these data suggest that the anergic state that characterizes CD25+ Tregs in vitro may not accurately reflect their responsiveness in vivo. These observations support a model in which Treg population dynamics are shaped by the local antigenic environment.

PMID:
12874258
PMCID:
PMC2194065
DOI:
10.1084/jem.20030315
[PubMed - indexed for MEDLINE]
Free PMC Article
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