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Arch Otolaryngol Head Neck Surg. 2003 Jul;129(7):771-4.

Three-dose vs extended-course clindamycin prophylaxis for free-flap reconstruction of the head and neck.

Author information

1
Division of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, 35233, USA. William.Carroll@ccc.uab.edu

Abstract

BACKGROUND:

Twenty-four hours of perioperative antibiotics provides effective prophylaxis for most head and neck cancer resections. Many reconstructive surgeons have been hesitant to apply this standard to free-flap reconstruction of the head and neck. This prospective clinical trial compared short-course and long-course clindamycin prophylaxis for wound infection in patients with head and neck cancer undergoing free-flap reconstruction.

METHODS:

Seventy-four patients were randomized to receive short-course (3 doses) or long-course (15 doses) clindamycin perioperatively. Wound infections, fistulas, and other postoperative complications were documented by faculty surgeons who were blinded as to treatment group.

RESULTS:

The differences in wound infections and other complications were statistically insignificant. No other independent predictors of wound complications emerged in this series of patients.

CONCLUSIONS:

Short-course clindamycin is as effective as long-course clindamycin in preventing wound infections after free-flap surgery for head and neck ablative defects.

PMID:
12874080
DOI:
10.1001/archotol.129.7.771
[Indexed for MEDLINE]

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