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Arch Dermatol. 2003 Jul;139(7):922-4.

Successful treatment of anogenital lichen sclerosus with topical tacrolimus.

Author information

1
Department of Dermatology, University of Münster, Münster, Germany. bohmm@uni-muenster.de

Abstract

BACKGROUND:

Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice.

OBSERVATIONS:

Three prepubertal girls and 3 adults (2 men, 1 woman) were treated with 0.1% tacrolimus ointment once daily. All patients experienced complete resolution with long-lasting remission for up to 1 year. No major adverse effects were observed, and treatment was well tolerated.

CONCLUSIONS:

Topical tacrolimus is a promising novel agent in the treatment of lichen sclerosus of the anogenital area. A major advantage over topical corticosteroids is the lack of skin atrophy. Further clinical trials are warranted to confirm our findings.

PMID:
12873890
DOI:
10.1001/archderm.139.7.922
[Indexed for MEDLINE]
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