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Pain Med. 2003 Jun;4(2):135-40.

Modafinil treatment of opioid-induced sedation.

Author information

1
Alpine Pain and Addiction Medicine, Salt Lake City, Utah 84107, USA. lynnw@alpinemedical.com

Abstract

STUDY OBJECTIVE:

The purpose of this study was to assess the efficacy of modafinil in combating opioid-induced sedation.

DESIGN:

A 1-year retrospective chart review of all patients receiving modafinil, a wake-promoting agent, to treat opioid-induced sedation. Opioid-induced sedation was measured using Epworth Sleepiness Scale (ESS).

SETTING:

Outpatient, private practice.

PATIENTS:

Eleven adult patients, six female and five male, being treated with opioids for chronic, nonmalignant pain.

RESULTS:

A significant decrease was observed between pretreatment and posttreatment ESS measurements during modafinil treatment.

CONCLUSION:

The results suggest an improvement in opioid-induced sedation in patients treated for nonmalignant pain.

[Indexed for MEDLINE]

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