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J Inherit Metab Dis. 2003;26(1):87-8.

Allopurinol challenge tests performed before and after living-related donor liver transplantation in citrullinaemia.

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1
Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan.

Abstract

We performed allopurinol challenge tests to evaluate the metabolic state of a citrullinaemic patient who received a living-relative donor liver transplant. Before transplantation, large amounts of orotic acid and orotidine were excreted during the challenge test. Following transplantation, excretion of these compounds in response to allopurinol was normalised. The challenge test was a safe and useful method to evaluate the metabolic state of the patient.

PMID:
12872848
[Indexed for MEDLINE]
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