Format

Send to

Choose Destination
See comment in PubMed Commons below
Biol Cell. 2003 May-Jun;95(3-4):221-8.

The RNA binding protein FMRP: new connections and missing links.

Author information

  • 1UPR 9002, Institut de Biologie MolĂ©culaire et Cellulaire, 15, rue RenĂ©-Descartes, 67084 Strasbourg cedex, France.

Abstract

The loss of the fragile X mental retardation protein (FMRP) is responsible for the most common cause of inherited mental retardation called the fragile X syndrome. FMRP is suspected to participate in the synaptic plasticity of neurons by acting on posttranscriptional control of gene expression. FMRP is an RNA binding protein that associates with mRNAs together with other proteins to form large ribonucleoprotein complexes. These complexes are proposed to participate in the transport, localization and translation of target mRNAs. Progress has been made recently in the identification of the mRNAs and the proteins present in these complexes and a possible connection with the micro-RNA dependent regulatory pathway has been established.

PMID:
12867085
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center