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Curr Biol. 2003 Jul 15;13(14):R574-6.

Insulin signaling: GLUT4 vesicles exit via the exocyst.

Author information

1
The Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY 11794-8651, USA. kanzaki@pharm.sunysb.edu

Abstract

The localization of the GTP-binding protein TC10 to lipid raft microdomains has been suggested to play a role in the stimulation of GLUT4 translocation. The exocyst has now been identified as a downstream target for TC10, directing GLUT4-containing vesicles to the site of fusion.

PMID:
12867054
[Indexed for MEDLINE]
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