[Peroxisome proliferator-activated receptors (PPAR) in pathophysiology of the circulatory system and prospective use of agonists of these receptors in therapy]

Postepy Hig Med Dosw. 2003;57(2):199-217.
[Article in Polish]

Abstract

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors which regulate the expression of target genes. Three types of PPAR have been identified: PPAR alpha, PPAR beta/delta and PPAR gamma. The known endogenous PPAR ligands are polyunsaturated fatty acids and eicosanoids, such as 15-deoxy-delta 12,14-prostaglandin J2 and leukotriene B4. Two classes of drugs, fibrates and thiazolidinediones, bind to PPAR alpha and PPAR gamma, respectively. PPARs are involved in the regulation of the lipid metabolism and adipogenesis but are also expressed in the vasculature. PPARs activators inhibit inflammatory reactions within the vascular wall, inhibit vascular smooth muscle cells migration and proliferation and affect foam cells formation by changing the expression of scavenger receptors. PPAR agonists lower blood pressure and improve endothelial function in different animal models of hypertension as well as in humans. PPAR gamma ligands inhibit the development of atherosclerosis in LDL receptor deficient and apolipoprotein E deficient mice and in diabetic humans. PPAR gamma agonists have also been shown to attenuate myocardial hypertrophy and protect against ischemia-reperfuion injury.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Arteriosclerosis / physiopathology
  • Blood Circulation / drug effects
  • Blood Circulation / physiology*
  • Cardiovascular Diseases / physiopathology*
  • Hemostasis / physiology
  • Homocysteine / metabolism
  • Humans
  • Muscle, Smooth, Vascular / metabolism
  • Oxidative Stress / physiology
  • Receptors, Cytoplasmic and Nuclear / antagonists & inhibitors
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Transcription Factors / antagonists & inhibitors
  • Transcription Factors / metabolism*
  • Vasculitis / metabolism

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • Homocysteine