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J Postgrad Med. 2003 Jan-Mar;49(1):17-20.

Prevention of reperfusion lung injury by lidocaine in isolated rat lung ventilated with higher oxygen levels.

Author information

1
University of Texas Health Center at Tyler, 11937 US Hwy 271, Tyler, TX 75708, USA. kumuda@uthct.edu

Abstract

BACKGROUND:

Lidocaine, an antiarrhythmic drug has been shown to be effective against post-ischaemic reperfusion injury in heart. However, its effect on pulmonary reperfusion injury has not been investigated.

AIMS:

We investigated the effects of lidocaine on a postischaemic reperfused rat lung model.

MATERIALS AND METHODS:

Lungs were isolated and perfused at constant flow with Krebs-Henseilet buffer containing 4% bovine serum albumin, and ventilated with 95% oxygen mixed with 5% CO2. Lungs were subjected to ischaemia by stopping perfusion for 60 minutes followed by reperfusion for 10 minutes. Ischaemia was induced in normothermic conditions.

RESULTS:

Postischaemic reperfusion caused significant (p < 0.0001) higher wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure compared to control lungs. Lidocaine, at a dose of 5mg/Kg b.w. was found to significantly (p < 0.0001) attenuate the increase in the wet-to-dry lung weight ratio, pulmonary arterial pressure and peak airway pressure observed in post-ischaemic lungs.

CONCLUSION:

Lidocaine is effective in preventing post-ischaemic reperfusion injury in isolated, perfused rat lung.

PMID:
12865565
[Indexed for MEDLINE]
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