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J Cell Biochem. 2003 Jul 1;89(4):653-62.

Effect of glucose concentration on activation of the ASK1-SEK1-JNK1 signal transduction pathway.

Author information

1
Department of Surgery, University of Pittsburgh, The Hillman Cancer Center G.5a, 5117 Centre Ave., Pittsburgh, PA 15213, USA. leeyj@msx.upmc.edu

Abstract

Recently, acute total glucose deprivation has been shown to cause activation of ASK1-MEK-MAPK signal transduction and dissociation of glutaredoxin (GRX) from apoptosis signal-regulating kinase 1 (ASK1). In this study, we investigated whether clinically relevant concentrations (0.01-0.1 mM) of glucose promote ASK1 activation. We observed that a prominent activation of JNK1 occurred at a glucose concentration less than or equal to 0.01 mM. Similar to JNK1 activation, we also observed that low glucose-induced ASK1 activation, dissociation of GRX and thioredoxin (TRX) from ASK1, dimerization of ASK1, and association of Daxx and TRAF2 with ASK1 significantly occurred at a glucose concentration less than or equal to 0.01 mM.

PMID:
12858332
DOI:
10.1002/jcb.10541
[Indexed for MEDLINE]

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