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Mamm Genome. 2003 May;14(5):323-34.

Cloning, functional study and comparative mapping of Luzp2 to mouse chromosome 7 and human chromosome 11p13-11p14.

Author information

1
Life Sciences Division, Oak Ridge National Laboratory, University of Tennessee, Graduate School of Genome Science and Technology, Oak Ridge, Tennessee, USA.

Abstract

A novel leucine-zipper gene, leucine zipper protein 2 (Luzp2), has been cloned as part of an aberrant deletion-fusion transcript in the chromosomal interval between Gas2 and Herc2 on mouse Chromosome 7 (Chr 7). Luzp2 is normally expressed only in brain and spinal cord. The human homolog of Luzp2 maps to Chr 11p13-11p14 by radiation-hybrid mapping and is deleted in some patients with Wilms tumor-Aniridia-Genitourinary anomalies-mental Retardation (WAGR) syndrome. Disruption of Luzp2 by gene targeting in mice did not result in any obvious abnormal phenotypes.

PMID:
12856284
DOI:
10.1007/s00335-002-2248-6
[Indexed for MEDLINE]
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