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EMBO Rep. 2003 Aug;4(8):781-6. Epub 2003 Jul 4.

A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster.

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1
Umeå Center for Molecular Pathogenesis, Umeå University, Sweden.

Abstract

The Drosophila melanogaster gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian Alk, which encodes a member of the Alk/Ltk family of receptor tyrosine kinases (RTKs). In humans, the t(2;5) translocation, which involves the ALK locus, produces an active form of ALK, which is the causative agent in non-Hodgkin's lymphoma. The physiological function of the Alk RTK, however, is unknown. In this paper, we describe loss-of-function mutants in the Drosophila Alk gene that cause a complete failure of the development of the gut. We propose that the main function of Drosophila Alk during early embryogenesis is in visceral mesoderm development.

PMID:
12855999
PMCID:
PMC1326337
DOI:
10.1038/sj.embor.embor897
[Indexed for MEDLINE]
Free PMC Article
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