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Trends Parasitol. 2003 Jul;19(7):286-9.

Nontranslated polyadenylated RNAs from Entamoeba histolytica.

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1
School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India.

Abstract

Protozoan parasites display a range of unusual molecular mechanisms that could be helpful for their survival in Nature. Among these parasites, Entamoeba histolytica is one of the most prevalent in developing countries such as India. Entamoeba histolytica produces at least four different unusual transcripts, IE, Tr, ehapt1 and UEE1, that are polyadenylated, but do not have significant open reading frames. Availability of large-scale sequence information has helped us to understand the nature of these sequences and their possible role. Entamoeba histolytica also encodes at least three classes of non-long-terminal-repeats containing retrotransposons, similar to mammalian long retrotransposable elements. This article describes the current status of our understanding of these transcripts and suggests a relationship between some of these transcripts and short retrotransposable element-like retro-elements present in many eukaryotes.

PMID:
12855374
[Indexed for MEDLINE]

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