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Biomed Pharmacother. 2003 Mar;57(2):67-77.

Cigarette smoking and cervical cancer: Part I: a meta-analysis.

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  • 1The Infectious Disease Service, Department of Medicine, Walter ReedMedical Center, Washington, DC, USA.


Cancer of the cervix is the third most common cancer among women worldwide and its etiology is not clearly understood. Human papillomavirus can be found in approximately 95% of cervical cancers, but it does not appear to be necessary or sufficient to induce malignancy. In 1977, Winkelstein suggested that cigarette smoking was a causative factor in the development of cervical cancer. We report a meta-analysis of cigarette smoking and cervical disease and conclude that the data support a role for cigarette smoking as a risk factor for cervical cancer. We propose a multifactorial hypothesis involving a virus-tar interaction as the etiology of cervical cancer.

[PubMed - indexed for MEDLINE]
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