Effect of established and putative anxiolytics on extracellular 5-HT and 5-HIAA in the ventral hippocampus of rats during behaviour on the elevated X-maze

Psychopharmacology (Berl). 1992;109(3):338-46. doi: 10.1007/BF02245882.

Abstract

One of the proposed mechanisms of action for the anxiolytic effects of the benzodiazepines is via a decrease in central serotonergic neurotransmission. The aim of this study was to combine in vivo microdialysis in the rat with behaviour on the elevated X-maze to determine changes in 5-HT release in the ventral hippocampus with concomitant measurement of behaviour. Twenty minutes exposure to the elevated X-maze resulted in an increase in extracellular 5-HT in the ventral hippocampus with no change in extracellular 5-HIAA. Restricting the rat to either the open or the closed arms produced an increase in extracellular 5-HT, however the increase in 5-HT when restricted to the open arms was not significantly greater than that on the closed arms. Forty minutes pretreatment with diazepam (2.5 mg kg-1 IP) significantly inhibited the increase in extracellular 5-HT in the ventral hippocampus and had an anxiolytic profile over 5 min and 20 min exposures of the rats to the X-maze. Diazepam had no effect on basal 5-HT levels before exposure to the X-maze but reduced extracellular 5-HT levels when the animal was returned to the holding cage. Forty minutes pretreatment with the .5-HT1A receptor partial agonist ipsapirone (1 mg kg-1 IP) significantly inhibited the increase in extracellular 5-HT in the ventral hippocampus but did not produce behaviour different from vehicle controls after 5 or 20 min periods on the X-maze.(ABSTRACT TRUNCATED AT 250 WORDS)

MeSH terms

  • Analysis of Variance
  • Animals
  • Anti-Anxiety Agents / pharmacology*
  • Behavior, Animal / drug effects*
  • Diazepam / pharmacology
  • Hippocampus / chemistry
  • Hippocampus / drug effects*
  • Hydroxyindoleacetic Acid / analysis*
  • Male
  • Microdialysis
  • Pyridazines / pharmacology
  • Pyrimidines / pharmacology
  • Rats
  • Serotonin / analysis*

Substances

  • Anti-Anxiety Agents
  • Pyridazines
  • Pyrimidines
  • F 2692
  • Serotonin
  • Hydroxyindoleacetic Acid
  • ipsapirone
  • Diazepam