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Bioorg Med Chem Lett. 2003 Aug 4;13(15):2459-63.

Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?

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Laboratoire de Chimie Biomoléculaire, INSERM U-382, IBDM, Université Méditerranée, Parc Scientifique de Luminy, 163 avenue de Luminy, case 901, 13288 Marseille Cedex 9, France.

Erratum in

  • Bioorg Med Chem Lett. 2003 Nov 17;13(22):4149.


In contrast to 5'-O-carbonate 3TC derivatives (23, 24), which are clearly 3TC prodrugs, the corresponding 3TC carbamates (15-21 and 25), found to be very stable compounds with respect to enzymatic hydrolysis (cellular lysates and culture cell media) and still active on both HIV-1 and HBV infected cells, may not be 3TC prodrugs. The antiviral properties as well as the mechanism of action of 3TC analogues have been studied and evaluated.

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