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Dev Cell. 2003 Jul;5(1):7-9.

Getting (chromosomes) loaded--a new role for timeless.

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1
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda, MD 20892, USA.

Abstract

A recent study in C. elegans reveals an unanticipated link between sister chromatid cohesion and the TIM-1 protein, a homolog of the Drosophila circadian rhythm protein TIMELESS. The phenotypes of tim-1 mutants suggest that cohesin subunits load onto chromosomes in a stepwise manner. Whether TIM-1 is also involved in circadian rhythms is discussed.

PMID:
12852847
[Indexed for MEDLINE]
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