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Rev Esp Enferm Dig. 2003 Jun;95(6):385-8, 381-4.

Incidence and epidemiological factors of hepatocellular carcinoma in Valencia during the year 2000.

[Article in English, Spanish]

Author information

1
Servicio de Hepatología. Hospital Clíinco Universitario. Facultad de Medicina. Valecia, Spain.

Abstract

AIM:

to ascertain the incidence and epidemiological factors of hepatocellular carcinoma in the Province of Valencia, Spain.

DESIGN:

a prospective study was made of hepatocellular carcinoma during the year 2000 collecting all diagnosed cases from four hospitals during that year.

RESULTS:

a total of 64 cases of hepatocellular carcinoma with a male predominance (42/22) and a mean age of 73.4 years (range of 42-90) were diagnosed. Incidence rate was 8.2 per 100,000, and cirrhosis was known to pre-exist in most cases, half of which were Child-Pugh A. Anti-VHC positive, alone or alcohol or virus B related was detected in 3 of every 4 cases. In the majority of the cases the tumours were located in the right hepatic lobe and the size at first diagnosis was less than 3 cm in 37.3% of the cases. Alpha-fetoprotein levels only exceeded 200 mg/ml in 37.3% of the patients and bore a good size relation to the tumour (R=0.245, p=0.003. No relation vis-à-vis aetiology with age, sex, tumour location or Child-Pugh stage was found.

CONCLUSIONS:

the incident rate of hepatocellular carcinoma in Valencia province during 2000 was 8.2 per 100,000 individuals. This lesion appeared more frequently in men between the ages of 60-80. Hepatitis C virus was the main etiologic agent found. Key words: Hepatocellular carcinoma. Incidence. Hepatitis C virus. Epidemiology. Child-Pugh grade. Alpha-fetoprotein.

PMID:
12852777
[Indexed for MEDLINE]

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