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Pflugers Arch. 2004 Feb;447(5):566-70. Epub 2003 Jul 8.

The sodium bile salt cotransport family SLC10.

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1
Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland. Bruno.Hagenbuch@access.unizh.ch

Abstract

The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na(+)/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

PMID:
12851823
DOI:
10.1007/s00424-003-1130-z
[Indexed for MEDLINE]
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