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Curr Opin Neurobiol. 2003 Jun;13(3):332-40.

The dynamic organization of postsynaptic proteins: translocating molecules regulate synaptic function.

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Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.

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  • Curr Opin Neurobiol. 2003 Aug;13(4):506.


Physiological roles for postsynaptic molecules in synaptogenesis and plasticity are under intense investigation. Recent imaging experiments, including GFP-based and single-particle tracking strategies, reveal rapid movement of synaptic components to and from the postsynaptic sites. Furthermore, specific patterns of neuronal activity and/or activation of specific transmitter receptors trigger selective translocation of postsynaptic components. These emerging dynamic properties of synaptic specializations add another layer of complexity to the signaling mechanisms of CNS synapses.

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