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Neural Netw. 2003 Jun-Jul;16(5-6):841-5.

Pharmacodynamic population analysis in chronic renal failure using artificial neural networks--a comparative study.

Author information

1
Kidney Disease Program, University of Louisville, Louisville, KY 40202, USA.

Abstract

This work presents a pharmacodynamic population analysis in chronic renal failure patients using Artificial Neural Networks (ANNs). In pursuit of an effective and cost-efficient strategy for drug delivery in patients with renal failure, two different types of ANN are applied to perform drug dose-effect modeling and their performance compared. Applied in a clinical environment, such models will allow for prediction of patient response to the drug at the effect site and, subsequently, for adjusting the dosing regimen.

PMID:
12850042
DOI:
10.1016/S0893-6080(03)00084-4
[Indexed for MEDLINE]

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