Format

Send to

Choose Destination
Fertil Steril. 2003 Jul;80(1):34-42.

Ortho Evra/Evra versus oral contraceptives: follicular development and ovulation in normal cycles and after an intentional dosing error.

Author information

1
Obstetrics, Gynecology, and Reproductive Sciences, University of Saskatchewan, Saskatoon, Canada. pierson@erato.usask.ca

Abstract

OBJECTIVE:

To compare the effects of the contraceptive patch to oral contraceptives (OCs) on follicular size and incidence of ovulation in normal cycles and after dosing errors.

DESIGN:

Randomized, open-label.

SETTING:

Twelve centers.

PATIENT(S):

One hundred twenty-four ovulatory women.

INTERVENTION(S):

Subjects received either the patch (groups 1 and 2) or one of three OCs. Correct dosing occurred in cycles 1, 2, 3, and 5. The following dosing errors were planned during cycle 4, a shortened 10-day cycle: [1] patch group 1 subjects wore one patch for 10 consecutive days; [2] for patch group 2 and OC subjects, 7 dosing days were followed by 3 drug-free days.

MAIN OUTCOME MEASURE(S):

Follicular size, as determined at each cycle by the maximum mean follicular diameter.

RESULT(S):

After a 3-day dosing error, follicular size was significantly smaller in the patch group (mean, 7.0 mm) vs. each OC group (range of means, 11.8-17.1 mm). Similar results were seen after proper dosing. The incidence of ovulation was significantly lower for the patch users than for women using OCs.

CONCLUSION(S):

Follicular size and incidence of ovulation were significantly reduced among contraceptive patch users compared with women using OCs in normal cycles and after planned dosing errors.

PMID:
12849799
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center