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Autoimmun Rev. 2003 Mar;2(2):57-62.

Modifications of arginines and their role in autoimmunity.

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Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands.


Posttranslational modifications of proteins often perform a key role in the biological functioning of proteins. Some of these modifications also change the immunogenicity of proteins and peptides and create 'self'-antigens which might induce autoimmune responses. In particular modifications of arginines within a defined protein context can lead to a specific B-cell immune response. This review discusses the generation of such modifications and their relevance for autoimmunity.

[Indexed for MEDLINE]

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