Format

Send to

Choose Destination
Nat Genet. 2003 Aug;34(4):377-8.

Essentiality, not expressiveness, drives gene-strand bias in bacteria.

Author information

1
Unité GGB, URA 2171, Institut Pasteur, 28 rue Dr. Roux, 75015 Paris, France. erocha@pasteur.fr

Abstract

Preferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution.

PMID:
12847524
DOI:
10.1038/ng1209
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center