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Ann N Y Acad Sci. 2003 Jun;991:107-10.

Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses.

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Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.


A paradigm shift in understanding Parkinson's disease (PD) and related disorders is emerging from studies showing that alpha-synuclein (AS) gene mutations cause familial PD; AS is abnormally nitrated, phosphorylated, and ubiquitinated; AS forms neuronal and glial inclusions; AS fibrillizes in vitro; and AS transgenic animals develop neurodegeneration with AS amyloid inclusions. Thus, PD and related synucleinopathies are brain amyloidoses that may share similar mechanisms and targets for drug discovery.

[Indexed for MEDLINE]

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