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Urol Int. 2003;71(1):118-21.

Leiomyosarcoma of the bladder in a retinoblastoma patient.

Author information

1
Department of Surgery, Cross Cancer Institute, Edmonton, Alta., Canada.

Abstract

We report a rare case of leiomyosarcoma in the bladder which occurred in an 18-year-old female with a prior history of retinoblastoma (RB). Molecular characterization of this tumor displayed a homozygous RB deletion and a reduced P53 expression. These results suggest that the loss of RB and P53 may have contributed to the initiation and/or progression of the leiomyosarcoma of the bladder in this patient.

PMID:
12845276
DOI:
10.1159/000071109
[Indexed for MEDLINE]

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