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J Nutr. 2003 Jul;133(7):2309-12.

Oral iodine toxicity in chicks can be reversed by supplemental bromine.

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1
Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA. dhbaker@uiuc.edu

Abstract

Four chick bioassays were conducted to quantify iodine (I) toxicity and its amelioration in young chicks. A supplemental I level from KI of 600 mg/kg depressed growth in chicks fed methionine-deficient diets but not in those fed methionine-adequate diets. An I dose level >or= 900 mg/kg was required to cause growth depression in chicks fed a methionine-adequate corn-soybean meal diet. Iodine intoxicated chicks also displayed neurological symptoms and extreme malaise, but dose levels up to 1200 mg I/kg had no effect on blood hemoglobin or hematocrit. Supplemental I levels of 1000-1500 mg/kg caused severe growth depressions that could be totally reversed by dietary addition of 50 or 100 mg/kg bromine provided as NaBr. Nuclear accidents or terrorist actions that result in I toxicity and thyroid cancer or goiter may benefit from use of NaBr as a therapeutic agent.

PMID:
12840198
[Indexed for MEDLINE]
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