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Traffic. 2003 Aug;4(8):503-11.

Nuclear functions for plasma membrane-associated proteins?

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Department of Infectious Diseases and Department of Cell Biology, Institut Cochin, INSERM U567, CNRS UMR 8104, Université Paris 5, 27 rue du Faubourg St Jacques, 75014 Paris, France.


There are a growing number of observations that proteins, which were initially thought to perform a specific function in a given subcellular compartment, may also play additional roles in different locations within the cell. Proteins found in adhesion and endocytic structures of the plasma membrane and which also traffic to the nucleus perhaps represent the more spectacular examples of this phenomenon. The mechanisms involved in the transport of these molecules through the nuclear pores and their potential nuclear functions are discussed.

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