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Mayo Clin Proc. 2003 Jul;78(7):830-5.

Topical corticosteroid treatment of dysphagia due to eosinophilic esophagitis in adults.

Author information

1
Division of Gastroenterology and Hepatology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA. arora.amindra@mayo.edu

Erratum in

  • Mayo Clin Proc. 2010 Sep;85(9):867.

Abstract

OBJECTIVE:

To describe the clinical features of patients with eosinophilic esophagitis and the use of topical corticosteroids for treatment.

PATIENTS AND METHODS:

We evaluated the charts of 21 patients with a diagnosis of eosinophilic esophagitis seen at the Mayo Clinic in Rochester, Minn, between September 1, 1999, and December 31, 2001. The diagnosis was based on the presence of a "ringed esophagus" or a tapered distal esophagus on upper endoscopy as well as the presence of a dense eosinophilic infiltrate on esophageal biopsy. All patients were treated with topical corticosteroids, and follow-up was performed by telephone interviews.

RESULTS:

The 15 men and 6 women ranged in age from 27 years to 66 years at diagnosis (mean, 36 [corrected] years). All had solid-food dysphagia for at least 6 years, and 15 patients had prior food impaction. Eighteen patients had either a ringed-appearing esophagus or smooth tapering in the distal esophagus. All patients had a dense eosinophilic infiltration (> 20 eosinophils per high-power field) in the mid or distal esophagus. Topical corticosteroid therapy for 6 weeks resulted in complete dysphagia relief in all patients and lasted a minimum of 4 months.

CONCLUSION:

Eosinophilic esophagitis is an entity associated with food dysphagia (predominantly in young adults) and a ringed or smooth tapered distal-appearing esophagus. Our study found no association with gastroesophageal reflux symptoms. Topical corticosteroid therapy was effective.

PMID:
12839078
DOI:
10.4065/78.7.830
[Indexed for MEDLINE]

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